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Drug Development "Fat Blocker" Xenical Weight Loss Pills in
United Kingdom
World Disease Weekly Plus
New Data Show Fast and
Significant Weight Loss With Xenical Weight Loss Pills Sustained Over Time
PR Newswire
Study Shows Weight Loss
Program With Xenical Weight Loss Pills Can Also Help Lower Blood Pressure in
Over Weight Hypertensive Patients.
PR Newswire
Growing the Market for
Weight Loss Drugs Including Xenical Weight Loss Pills
Carolyn Wilhelm
Weight Loss with Xenical
Weight Loss Pills Shown to Significantly Prevent or Delay Onset of Type 2
Diabetes in Over Weight Patients, According to New Four-Year XENDOS Study; -
Risk of Developing Type 2 Diabetes 67 Percent Lower in People Treated With
Xenical Weight Loss Pills.
PR Newswire
Drug Development Fat
Blocker Xenical Weight Loss Pills in United Kingdom
World Disease Weekly Plus
Xenical weight loss pills, a weight loss drug that works by reducing fat absorption in the body was launched in Britain.
Doctors said a two-year clinical trial showed that Xenical weight loss pills, plus a reduced fat diet, helped over weight people lose more than 15 percent of their body weight in a few short months.
"Xenical produces and will help you to maintain clinically significant weight loss," Dr. Nick Finer, a consultant endocrinologist, told a news conference to launch the treatment.
Unlike weight loss pills that suppress the
appetite, Swiss drugs giant Roche Holding' "fat blocker" drug is an approach
to treating obesity, a condition that affects tens of millions of people
worldwide. Clinical studies have shown that if you combine Xenical
with your weight loss effort you will lose to two times more weight than if
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"Obesity is now being recognized as a medical problem. We are now being given the tools to do something useful about it," said Professor Gareth Williams, University of Liverpool, in northwest England. "We have to do this as part of a plan," he added.
Roche denied media reports that Xenical would cost Britain's government-funded National Health Service (NHS) 700 million pounds ($1.18 billion), more than Pfizer's impotence drug Viagra, if most of the nation's 7.5 million obese adults received it.
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New Data Shows Fast
and Significant Weight Loss With Xenical Weight Loss Pills Sustained Over
Time
PR Newswire
BASEL, Switzerland -- The weight loss medication Xenical helps patients achieve rapid and sustained weight loss according to the results of a new study designed to reflect real world usage of Xenical in clinical practice.(1)
The 12 month study of 2430 overweight men and women ,
was designed to assess the effectiveness of Xenical slimming pills in
patients who are responsive to treatment. Patients who achieved 10 per cent
(approximately 16kg) weight loss after 3 months and maintained this after a
further 3 months of Xenical treatment, were followed for one year. During
this time weight loss and other health improvements, such as reductions in
blood pressure, were assessed.
The results suggest that the efficacy of Xenical weight loss pills in a
real-life clinical practice setting is even greater than that demonstrated
previously in clinical trials:
-- The greatest weight loss was seen in the first four weeks of treatment, with an average weight loss of 9.1 kg
-- Three out of four people achieved 15 per cent weight loss by month three, losing an average of 13 kg
-- By month five 78 percent of these people had maintained at least 85 per cent weight loss, with an average weight loss of 18.4 kg
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-- The average weight loss after one year was 24.6 kg. One in two patients in the study lost more than 25 per cent of their initial weight, and over 8 in ten people lost more than 15 per cent -- an amount of weight loss shown to clinically improve the health and well-being of overweight people(2)
Commenting on the results, lead study investigator Professor Hermann Toplak from the Karl-Franzens-Universitat, Graz, Austria said, "These results demonstrate the significant benefits of rapid and continuous weight loss with Xenical in a clinical practice setting. Patients who respond rapidly to treatment continue with treatment and achieve long-term weight loss success."
Xenical weight loss pills results also demonstrated significant health gains associated with weight loss with Xenical. Specifically, individuals treated with Xenical weight loss pills achieved improvements in:
- Waist circumference: An average
reduction of 14.8 cm was achieved after one year. Excess fat around the
waist is associated with insulin resistance, high blood sugar, high
cholesterol levels and high blood pressure.
- Blood pressure: In patients with
hypertension, mean systolic and diastolic blood pressure were reduced by
18.1mmHg and 9.9mmHg respectively.
- Cholesterol: The lipid profile of patients was markedly improved: mean LDL-cholesterol ('bad' cholesterol) levels were reduced by 16.7 per cent and mean total cholesterol levels by 22.6 per cent. The reductions in blood pressure are a key finding as the number of overweight people with hypertension is almost three times higher than the number of adults with a healthy weight.
Xenical is the only prescription weight-loss medication, which can be used in patients with hypertension or uncontrolled hypertension.
Xenical
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unique. Unlike appetite suppressants, which have a history of
withdrawals because of safety concerns, Xenical weight loss pills do not act on
the central nervous system. As a result of Xenical slimming pill's
non-systemic mode of action, it has a safety and tolerability profile, which
makes it appropriate for use in a wide range of individuals. This is particularly
important within the area of overweight /obesity, where a significant
number of people suffer from, or are at risk of cardiovascular disease.
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References:
1. Toplak H. Oral Presentation at Seville, Roche Event, 31
2. Goldstein DJ. International Journal of Obesity. 16:397-415
3. Pi-Sunyer FX. "Medical Hazards of Obesity." Ann Intern Med
119: 655-660.
4. Yanovski S et al. Obesity. NEJM 2002; 346 (8): 591-602
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Study Shows Weight
Loss Program With Xenical Weight Loss Pills Can Also Help Lower Blood
Pressure in Overweight Hypertensive Patients.
PR Newswire
Xenical Weight Loss Pills Will Help To Decrease Your Blood Pressure
Results from a multi-center clinical trial headed by researchers show that weight loss induced by Xenical weight loss pills can significantly reduce elevated blood pressure in overweight individuals.
David Calhoun, M.D., medical director of The Vascular Biology and Hypertension Program and one of the lead investigators, said the results are of particular importance because persistent obesity often reduces the effect of antihypertensive medications.
The study investigated the effect of Xenical weight loss pills on weight loss and blood pressure in patients with treated but inadequately controlled high blood pressure. Xenical induce weight loss by blocking the absorption of dietary fat.
Calhoun said researchers found that those patients treated with Xenical weight loss pills experienced a significantly greater decrease in diastolic blood pressure compared with placebo (sugar pill) and significantly greater weight loss. They also found that a greater percentage of patients who received Xenical weight loss pills obtained a significant blood pressure benefit by reducing their blood pressure to a normal level or by at least 10 points.
"In addition to its favorable effect on blood pressure, slimming with Xenical weight loss pills was found to produce a significantly greater reduction in cholesterol levels," David Calhoun, M.D., medical director of The Vascular Biology and Hypertension Program, said. Patients taking Xenical weight loss pills experienced a tenfold greater reduction in total cholesterol level compared with placebo (sugar pill), and threefold greater reduction in low-density lipoprotein (LDL) cholesterol. Buildup of cholesterol is the most common cause of coronary heart disease, Calhoun, M.D. said.
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Growing the Market for
Weight Loss Drugs Specifically Xenical Weight Loss Pills
Carolyn Wilhelm
Leading the market is Xenical, with $346 million in sales, followed by Reductil with $202 million, based on data from IMS Health.
Competing directly with Xenical weight loss
pills in the weight loss
drug market is Knoll's Reductil. Reductil, a reuptake inhibitor
functions on the brain to control hunger by inhibiting the reuptake
of the neurotrausmitter norepinephrine and serotonin.
Reductil Sibutramine functions differently than the weight loss drug
Phentermine,
which, besides preventing the reuptake of serotonin, acts to
increase the release of serotonin into the brain, explains a Knoll
official. Reductil has been shown in numerous clinical studies to
help you lose 2-3 times more weight than if you attempted dieting
without
Reductil
weight loss pills.
Ms. Coe attributes Xenical's success to its
high level of product differentiation, principally achieved by the
drug's mechanism of weight loss action. "Xenical acts non-systemically in the
gastrointestinal tract, not requiring entry into the bloodstream or
brain, to block the absorption of dietary fat by
one-third," a Roche official explains. "While other anti-obesity
treatments act upon the central nervous system by affecting neurons
in the brain to suppress appetite, Xenical acts locally in the
intestine to prevent partial absorption of fat by about 30 percent."
Secondary to the Xenical's ability to block the absorption of fat, a side
effect of the drug is a change in bowel habits.
Health care providers too are beginning to realize the need for drug treatment to help combat their patients who are overweight, Last year, only 25 percent of healthcare providers covered prescription weight loss drugs, but there are now at least 46 percent that do so. In the past being overweight was considered a social issue, related to a lack of willpower and exercise. More and more, being overweight is being recognizing as a serious, life-threatening disease. Some observers even term obesity an epidemic.
Over half (55 percent) of all European adults
are considered overweight or obese, according to a 2007 study
conducted by the National Heart, Lung, and Blood Institute (NHLBI)
and National Institute of Diabetes and Digestive and Kidney Diseases
(NIDDK). Obesity is the second leading cause of preventable death in
the Europe. Costs associated with obesity-related diseases amount to
$100 billion annually.
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Weight Loss with
Xenical Weight Loss Pills Shown to Significantly Prevent or Delay Onset of
Type 2 Diabetes in Over Weight Patients, According to New Four-Year XENDOS
Study; - Risk of developing type 2 diabetes 67 percent lower in people
treated with Xenical Weight Loss Pills.
PR Newswire
London -- Xenical weight loss pills plus diet and changes in lifestyle habits significantly prevented overweight individuals from developing type 2 diabetes, according to a major four-year clinical study presented today at the 9th International Congress on Obesity in London. This is the first time that a weight loss medication was shown to prevent or delay the onset of type 2 diabetes in an at-risk patient population. The XENDOS trial studied 3,304 obese Swedish patients over a four-year period who were randomized into two trial arms: Xenical plus diet and lifestyle intervention and placebo plus diet and lifestyle intervention alone. XENDOS also is the first large-scale and longest study to examine the efficacy and safety of a weight loss medication.
XENDOS Xenical Weight Loss Pill Results:
-- Xenical weight loss pills plus diet is shown to
be significantly better than diet alone
in preventing or delaying the development of type 2 diabetes
-- The risk of developing type 2 diabetes was 47 percent lower in patients
treated with Xenical plus diet compared to diet alone
-- Xenical-treated patients also showed significant
improvements in
cardiovascular risk factors such as blood pressure and lipid profiles
compared with placebo the placebo treated patients
-- Treatment with Xenical for four years was safe
and effective and well
tolerated. Xenical now is the only weight loss medication available
whose safety and efficacy has been studied for this length of time
-- Weight loss, both in the short- and long-term,
was significantly
greater with Xenical plus diet and lifestyle intervention compared with
diet and lifestyle intervention alone (-11.4 vs -7.5 kg at one year and
-6.9 vs -4.1 kg at four years)
-- Weight loss was successfully maintained in the
long-term, with almost
twice as many Xenical treated individuals compared to placebo losing more
than 10 percent body weight at the end of four years of treatment (26%
vs 16%). Even more patients had lost more than 5 percent body weight
after four years (53% vs 37%), an amount that has been shown to have
clear health benefits.
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"Against the background of several studies that show
lifestyle intervention in the prevention of diabetes to be successful, it is
a significant step forward to be able to show that treatment with Xenical
plus diet in combination with lifestyle modification is more effective than
diet and lifestyle intervention alone in both diabetes prevention and weight
loss," said Professor Lars Sjostrom, Sahlgrenska University Hospital,
Gothenburg, Sweden, principal investigator of the XENDOS study.
More About Xenical Weight Loss
Pills
Approved for slimming maintenance of lost weight, and
the reduction of risk of weight regain after prior weight loss when used
with a reduced-calorie diet, Xenical is the only non-systemically acting
gastrointestinal lipase inhibitor. Its mechanism of action is to prevent
one- third of dietary fat from being absorbed.
Slimming with Xenical weight loss pills also has resulted in improvements in many cardiovascular risk factors such as high blood pressure, high cholesterol and diabetes, compared with diet alone. Xenical has an established safety profile and is the most extensively studied weight management treatment to date. Xenical weight loss pills have been used in over 48 million individuals worldwide.
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References:
(1) National Diabetes Education Program news release from the American
Diabetes Association. "As Diabetes Epidemic Surges, HHS and ADA Join
Forces to Fight Heart Disease, the Leading Cause of Death for People
with Diabetes."
(2) Centers for Disease Control and Prevention. "Diabetes Rates Rise
Another 6 Percent in 2009."
www.cdc.gov/di abetes/news/docs/010126.htm
(3) Diabetes Prevention Study (DPS). NEJM, Prevention of type
2 diabetes mellitus by changes in lifestyle among subjects with
impaired glucose tolerance. Tuomilehto et
(4) Diabetes Prevention Program (DPP). NEJM, Reduction
in the incidence in type 2 diabetes with lifestyle intervention or
metformin
(5) American Diabetes Association and National Institute of Diabetes,
Digestive and Kidney Diseases position statement. Diabetes Care,
Vol 25, . The prevention or delay of type 2
diabetes. Sherwin et al
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