Reductil UK News,
Information on Reductil
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The following Reductil UK news section
represents a comprehensive list of articles addressing the use of Reductil
in promoting significant weight loss:
First Two-Year Clinical Data For
Reductil Demonstrates Just How Effective Reductil is in Maintaining Long-Term*
Weight Loss.
PR Newswire
les that address the use of Reductil slimming pills for fast
Growing the Market for Anti-Obesity
Drugs
Chemical Marketer Reporter
Effects of Reductil Plus Orlistat in
Obese Women
Nutrition Research Newsletter
Reductil Evaluated for Weight
Maintenance
Psychopharmacology Update
First Two-Year Clinical Data
For Reductil Demonstrates Just How Effective Reductil is in Maintaining
Long-Term* Weight Loss.
PR Newswire
Results from the second phase of the STORM study -- Reductil Trial in Weight Reduction and Maintenance -- released today at the European Congress on Obesity in Milan suggest that Reductil slimming pills are effective in helping most people maintain initial six month weight loss for up to two years. According to the study, 87 percent of people taking Reductil maintained more than a ten percent weight loss (compared to 49 percent in placebo, sugar pill group) and 65 percent maintained more than a 15 percent weight loss (compared to 19 percent in the placebo group).
"There was a significant difference between the active agent and a placebo in the STORM study that has important clinical benefits," remarked Arne Astrup, M.D., Ph.D., STORM investigator and professor of human nutrition at the University of Denmark.
For many people, maintaining weight loss is a difficult task. According to Kelly Brownell, Ph.D., director of the Yale Center for Eating and Weight Disorders at Yale University in New Haven, Conn., "Maintenance is essential for realizing the health and psychological benefits of initial weight loss. Without the right tools, regain of lost weight can be an all too common experience." Reductil will help you lose the initial weight and now studies are showing that individuals are keeping the weight off for the lowng term.
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Reductil works by affecting chemicals in the brain involved in regulating appetite and helps people overcome one of the biggest barriers to losing weight, because it helps them feel full so they can eat less -- a feeling also known as satiety. Since its launch in February 1998, Reductil has been taken by more than eight million individuals in Europe.
Health Benefits of Modest Weight Loss and Maintenance Following Weight Loss With Reductil
STORM investigator, Nick Finer, M.D., with the Centre for Obesity Research at Luton and Dunstable Hospital in the United Kingdom said, "Usually we say that an acceptable weight loss is five percent, and that five to 10 percent is highly beneficial in terms of cardiovascular risk factors and co-morbidities, which were all going in the right direction in this study."
Clinical studies with Reductil slimming pills have shown it to be a well tolerated, safe and effective weight management medication with the majority of people losing between five and 10 percent of their body weight quickly. Early findings from the STORM study appear to reconfirm previous studies showing weight loss and maintenance of weight loss.
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About Reductil
Reductil is well tolerated, and allowed individuals to lose a
significant amount of weight. In fact several clinical studies revealed that
individuals that combine Reductil with their dieting efforts lost two to
three times more weight than those individuals that attempted dieting
without Reductil.
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Growing the Market for
Weight Loss Drugs
Chemical Marketer Reporter
The anti-obesity drug market has seen a major upswing in growth during the past years, offering fresh alternatives for drug-assisted weight loss. With tKnoll's Reductil (sibutramine) in and Roche's Xenical (orlistat) , the market has grown 70 percent in just one year. These two weight loss drugs work.
Leading the market is Reductil, with $346 million in sales, followed by Xenical with $202 million, based on data from IMS Health.
Competing directly with Xenical in the
diet drug market is Knoll's Reductil. Reductil, a reuptake inhibitor
functions on the brain to control hunger by inhibiting the reuptake of the
neurotrausmitter norepinephrine and seratonin. Sibutramine functions
differently than the diet drug phentermine, which, besides preventing the
reuptake of serotonin, acts to increase the release of serotonin into the
brain, explains a Knoll official. Reductil has been shown in numerous
clinical studies to help individuals lose 2-3 times more weight than those
individuals that attempted dieting without Reductil.
Ms. Coe attributes Xenical's success to its high level of product differentiation, principally achieved by the drug's mechanism. "Xenical acts non-systemically in the gastrointestinal tract, not requiring entry into the bloodstream or brain, to block the absorption of dietary fat by approximately one-third," a Roche official explains. "While other anti-obesity treatments act upon the central nervous system by affecting neurons in the brain to suppress appetite, Xenical acts locally in the intestine to prevent partial absorption of fat by about 30 percent." Due to the drug's ability to block the absorption of fat, a side effect of the drug is a change in bowel habits.
Health care providers too are beginning to realize the need for drug treatment to help combat obesity, Last year, only 30 percent of healthcare providers covered prescription drugs for obesity, but there are now at least 36 percent that do so. In the past obesity was considered a social issue, related to a lack of willpower and exercise. More and more, obesity is being recognizing as a serious, life-threatening disease. Some observers even term obesity an epidemic.
Over half (55 percent) of all European adults are
considered overweight or obese, according to a 1998 study conducted by the
National Heart, Lung, and Blood Institute (NHLBI) and National Institute of
Diabetes and Digestive and Kidney Diseases (NIDDK). Obesity is the second
leading cause of preventable death in the Europe. Costs associated with
obesity-related diseases amount to $100 billion annually.
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Effects of Reductil Plus
Orlistat in Obese Women
Nutrition Research Newsletter
Two medications, Reductil and Xenical are currently approved by NHS for weight loss and maintenance of weight loss. Reductil is a combined norepinephrine-serotonin reuptake inhibitor, whereas Xenical is a gastric and pancreatic lipase inhibitor. In controlled trials, Reductil was associated at one year with a 17% reduction in initial weight, andXenical with a 16% reduction.
Resent clinical trial have shown that if you combine both Reductil and Xenical in a healthy diet program you will lose three times more weight than attempting to diet without the use of these weight loss medications. Doctors have been very enthusiastic with this latest positive news prescribing both Reductil and Xenical to their patients.
Individuals in the studies that received both Reductil and Xenical were prescribed one Reductil 15mg dose in the afternoon before lunch. With regards toXenical researchers decided not to prescribe Xenica in the morning (similar to Reductil because many of the participants stated that they did not eat breakfast, and the evening snack appeared to present a greater risk for overeating than did breakfast. So patients were instructed to limit their fat intake to a maximum of 30 g per meal (or snack), and 60 g per day and to take one Xenical 120mg dose before their two main meals of the day.
Secondary to the advent of the internet, you can now communicate openly and
candidly with a licensed doctors online. You can now buy prescription drugs,
such as,
Reductil and
Xenical online with no prior prescription from the privacy of there own
home. Instead of the traditional visit to a doctor's office, you are
requested to complete a medical questionnaire that addresses your medical
history. This is information that is required by a licensed doctor so that
he/she can make a decision whether the desired medicine is appropriate for
an individual's current condition.
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"My patients that have struggled in the past are now losing a significant
amount of weight and they are keeping the weight off for the long term with
the help of Reductil and Xenical."
James Passilla, M.D.
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Reductil Evaluated for Weight
Maintenance
Psychopharmacology Update
Investigators conducted a randomized, double-blind trial to assess the usefulness of sibutramine (Meridia) in maintaining substantial weight loss over two years.
Eight European centers recruited 605 obese patients (body mass index [BMI] of 30-45 kg/[m.sup.2]). Patients received 10 mg/d of Reductil for six months and followed an individualized 600 calorie-per-day deficit program based on their resting metabolic rates. Then, 467(77%) of patients with more than a 5 percent weight loss were randomly assigned to received 10mg daily of Reductil (n=352) or placebo (n=115) for 18 months further. The dose of Reductil was increased up to 15 mg daily if weight regain occurred.
The primary outcome measure of the study was the number of patients at year two who had maintained at least 80 percent of the weight loss between baseline and month six. Secondary outcomes of the study were changes in uric acid concentrations and glycemic and lipid variables.
The results were that the patients in the Reductil group maintained 80 percent or more of their original weight loss compared with nine 16 percent of the patients in the placebo (sugar pill) group.
In addition, patients had substantial decreases in triglyceride, cholesterol, insulin, uric acid and other levels, which were sustained in the Reductil group but not the placebo (sugar pill) group.